Suffering with arthritis? Do you really need a joint replacement?

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Wasted treatments for bone and joint pain have racked up millions, in medical bills so far. Patients, who had been suffering with millions of arthritic conditions like osteoarthritis, spinal cord injury, etc. have gone through treatments like viscosupplementation, steroidal injections, simple PRP shots, etc; which generally are not recommended and as well accounted for 1/3rd of their total medical expenses. Many patients would opt for the surgery, with an intention to save some money on unrealistic approach; although, going straight under the knife is as well not recommended. Enough evidences have gathered in this regard, to support the statement that joint replacement surgeries have never been a suitable option; either because the treatments are very expensive and still are not helpful, or because they are as well associated with other opportunistic infections, which are difficult to avoid.

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Considering the need of an hour, scientists were so far desperately looking for an alternative treatment option, to get along, for not doing surgery. Accordingly, science has supported the fact that our own body has been powered with the most robust healing system, in the form of stem cells. They have been identified as the fundamental raw materials, which are being used in case of many day to day effects on the body, causing cellular degeneration or loss. These stem cells can be differentiated to cells of multiple types and hence can manage with the cellular loss. Read More

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Precision Medicine: Changing our perspectives on healthcare

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A day is not too far away when you will be directly prescribed with personalized medicine based on how quickly your body accepts it and facilitates faster processing towards the same.

However, today’s conventional medicine is quite convinced with the assumption that patients with a particular diagnostic condition should get the same first line of treatment, knowing the fact that it can only be 30-60% effective. In this regard, offering tailored therapy with the best possible response as well as the highest safety margin should be treated as the blockbuster approach. And this can be achieved through the acceptance of precision medicine or personalized medicine.

What exactly is personalized medicine?

Personalized medicine is an emerging approach for better patient management in the form of offering a cost-effective solution for the effective treatment outcome. In other words, personalized medicine can offer a move away from traditional “one size fits all” therapeutic module and further emphasize to manage the disease as per patient’s genetic predisposition and body’s capacity. The proposed new scientific discipline was being developed from the confluence of biochemical, pharmacological as well as the genetic makeup of an individual; further seeking to understand all the cellular as well as molecular underpinnings of particular diseased conditions. Since, personalized medicine is also being identified as the precision medicine, for being an extension of traditional therapeutic approach to treat the diseased condition; but with greater understanding and with greater precision.

Thus, personalized medicine helps each patient to enable early diagnosis of the diseased condition, better risk assessments,and optimum treatment; further improving overall healthcare and reduce the treatment cost considerably.

The historical landscape of personalized medicine

Over the past decade or so, substantial evidence have been gathered to confirm that a substantial percentage of variable treatment out comesare dependent upon a number of factors like genetic predisposition, immunological strength of a person, age, environmental impact, stress, nutritional level, epigenetic factors,etc. It should also crucially note different patterns of therapeutic responses depending upon geographical as well as ethical basis of a population.

Personalized medicine: The Stem Cells Theranostic?

Precision medicine, by contrast, focuses on the targeted application of a drug or another therapeutic module further allowing specific treatment outcome; with the primary goal of maximizing the therapeutic outcome and minimizing the risk of any other side effects. In particular, this approach has largely been warranted by the regenerative cellular medicine in the form of multiple cascades of interaction between infused cells and the host cells to decisively influence and accelerate therapeutic outcome.

With the advancements on basic science and technology associated with stem cell therapeutics, researchers are now working towards solving many different questions such as:

  • How to translate the existing platform of stem cell research towards the therapeutic application of stem cells?
  • How to optimize adequate clinical effectiveness and predictive safety, while performing stem cell therapy?
  • How to precisely plan targeted delivery of stem cells, in order to facilitate better coordination of stem cells with that of the patients own cells?
  • How to exploit stem cells for multi-dimensional, decisive treatment outcome?

Thus, there are several important considerations that need to be taken care of, while considering personalized stem cell therapy for clinical applications.

Important properties of stem cells have implications for personalized medicines

The diminished euphoria of stem cells is forcing scientists, medical professionals as well as the general public to re-examine different types of stem cells and their unique properties that would effectively allow regeneration of lost cells and facilitate functional attributes of tissue. In this regard, researchers are working towards implementation of the trans disciplinary approach by considering all aspects of science and technology to achieve better stem cell migration at the site of injury and facilitate tissue regeneration. Some of the important properties of stem cells that can be referred to as an implication towards precision medicines can be noted herewith:

  • Stem cells are immune-privileged, as in they cannot elicit any negative immune response in the patient body and prevent rejection.
  • Stem cells are immune-enhancers, by promoting and regulating good immune cells that are already present in our body; and thus, help in minimizing auto-immune destruction of the targeted
  • Stem cells are able to trans differentiate into multiple cells types like bone, neurons, cartilages,and pancreatic beta cells.
  • There is a possibility of both autologous as well as allogeneic therapy with the wide treatment spectrum depending upon the disease type.

Conclusion

Thus, the major focus and interest are towards application and exploitation of all the relevant properties of stem cells towards developing a brand-new tool for the tailored health care options based on our unique genetic as well as immunological make-up, environmental effect,and lifestyle. With the accumulation of large database and comparative analysis done on the same, both researchers and clinicians are optimistic towards the use of stem cells in personalized medicine.

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Painful Knees? Do you really want to undergo knee replacement?

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If you really want to second guess many orthopedic experts and patients, who agreed to undergo stem cells therapy for their chronic arthritic knee issues; as the best way to address the same, instead of going under the knife for knee replacement? Even if you wish to sort the issue, as a second-guesser; you have fair chances to go with stem cells therapy, after understanding its key benefits.

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The time being body’s own enemy, every one of us eventually experience some or the other sort of pain on our body. Sometimes, it may be originated with bad habits like poor posture maintenance and/or over exploitation of the tissue or may be genetic alterations. Through conventional treatment options, administration of steroidal drugs and anti-inflammatory shots like NSAIDS are the preferred choices, however, their effects seldom last for a longer period of time. Moreover, continuous consumption of these prescribed drugs is thought to be responsible for organ failure. When these organic band aids fail to heal, many people turn toward surgeries as the only possible option. However, number of recent studies do not suggest any effective outcome, confirming that surgeries don’t always work! Moreover, in many of the cases, the side effects due to other opportunistic infections and longer period of rehabilitation can worsen the pain than its pre-surgical counterpart.   Read More

I am worried…………. Is my child normal?

As a parent, you would obviously be very reluctant to believe that your precious bundle of joy is not behaving normally. However, you should as well understand that in case of autism, early interventions, ideally by the end of 1 and half years can make huge differences in reducing the symptomatic expression of the disorder and to cope up with your child’s ability to learn, grow and interact.

 

You apparently are at the best position to spot any warning abnormalities, behaviors and quirks during early developmental phase of your child. Although, your pediatrician is your valuable partner in evaluation; you should never discount the importance of your own observations, and the key is to educate yourself to distinguish abnormality from normal behavior.

Learn the early signs

The information shared herewith, can be referred as “red flags”, suggesting a child at a risk of autism; however, further evaluation is always very crucial as all children with autism don’t express all of them.

·         By the age of six months, if your baby is not looking at you, when being fed or doesn’t smile in return, if smiled at; it Read More

Advancells: Once upon stem cells!

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Stem cells were able to be differentiated into heart cells, stem cells could be transformed into bone matrix, a specific gene from stem cells can be mutated to generate embryonic like stem cells, stem cells……

One or two decades ago, when stem cells research had just begun to develop; its different potentials from exploring the early human development to possible replacement of damaged or defective cells were reflecting to be some hypothetical bedtime stories.

 

However, aggressive research and clinical developments initiated by the worldwide scientists, supported their so far hypothetical existence to be realistic. Many unique properties of different types of stem cells have been pinpointed, such as totipotent nature of embryonic stem cells, adult stem cells with limited potency to be tissue specific cells and induced pluripotent stem cells, futuristic alternatives to the embryonic stem cells.
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In this regard, the article is intended to summarize the top five findings, which have been proven to be game changers in approving their existence and future fates.

 
The markers of destiny
It was earlier thought that specific genes that have been identified as markers of different types of tissue related cells remain silent, until stem cells are in their undifferentiated state; however, researchers from the university of California and Los Angeles have explored the fact that different proteins mark these genes, early during the embryonic level; when cells can potentially be directed to perform wide range of future functions. In this regard, scientists are now putting in more efforts, to put insights, on better understanding of the pluripotency and the presence of these marks, in order to make sure that stem cells remain fully functional, even after their infusion.
Physical properties
Like different houses have different infrastructure, it has been recently discovered that the physical properties of stem cells can have better predictability about their most suited fate. Evidence have suggested that bone cells can be better developed from stiff stem cells, whereas fat can be easily formed from squishy, soft cells.
Right concoction of recipes
We all might have heard the story of Cinderella and her fairy grandmother! Even she had to use a right spell to make a pumpkin into a carriage! Similarly, to direct these stem cells towards being specific cell, it is necessary to have right blend of growth factors, nutrient medium and environment.  A team of researchers from the university of Canada, developed three different types of cardiac muscles, in vitro through right concoction of growth factors, stimulants, nutrients and micro environment. The data may further encourage us to believe that it is quite possible to create fully functional organs, outside the human body, through right recipes of stem cells.
Suicidal Tendencies
Scientists from the University of North Carolina have explored the fact that if the DNA is being damaged through environmental effects, like viral attack, radiations, etc.; stem cells can possibly kill themselves to halt further progression of unlikely conditions. It has been investigated that in order to prevent this accidental cellular suicide, stem cells have their own ‘poison apple’ that is being stored in their nucleus to prevent further cellular communication. Scientists are now fetching the fact deeper to aid the development of cellular therapies, perhaps to replace lost cells.
Meritorious Metamorphosis
The ability of stem cells to metamorphose into fully functional cell is being studied in depth to understand their internal mechanism and test potential treatments. 

Can stem cells therapy be beneficial for Ankylosing Spondylosis?

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Studies have solved the mystery of orthopedic conditions, wherein cellular senescence; a state whereby cells stop dividing, is a primary cause. Further analysis in these regards, suggest that targeting these cells could nevertheless be a promising way to prevent and/or stop the progression of these conditions.

Advancells-Ankylosing-SpondylitisAnkylosing spondylosis, also known as bamboo spine is a kind of arthritic condition, which can progressively lead to chronic pain and discomfort, in lower portion of the spine. Studies have significantly identified it to be an inflammatory condition, triggered due to immunological deregulation; majorly affecting bone and joints connection of the spine. Progressively, the inflamed vertebrae and joints will further be fused to each other, causing absolute loss of spinal flexibility and spinal curvature.

Since, symptomatic exhibition of AS is found to have genetic correlation; it is commonly being categorized as a lifelong disorder, however, certain environmental factors may trigger epigenetic conversion of gene, starting immune flare ups. The first symptoms of AS are reported to be visible by the age of 30; leading to long lasting pain and inflammation.

The disease is characterized by different common manifestations, such as:

  • Inflamed and painfully stiff joints
  • Pain in lower back, buttocks and also sometimes in legs.
  • AS may progress in some joints, causing them to produce new bones; especially due to fusion of one or more bones.
  • With progression, AS can limit body’s ability to perform physical task, productivity and thus, affect the quality of life.
  • Certain other symptoms may be associated with disease progression, like peripheral arthritis, psoriasis, inflammatory bowel disease, etc.
  • Many people with AS have as well complained about inflamed, painful eyes, which can progressively add on to the blurry vision.
  • In rare cases, vital organs may as well get affected, like lungs and hearts.

The condition has been reported to affect life of every individual very differently. Some may experience flare ups with some time intervals, however, the experience may never get worse; whereas, in some other case, the disease may progress rapidly, with symptoms worsening over the period of time.

Spine

Spine is the first shelter of symptoms in case of AS. A person may usually feel burning sensation that may radiate towards the buttocks and thighs. With its progressive appearance, the inflammation may usually spread on the spine, causing severe pain and stiffness, affecting posture.

Joints

Painful and inflammatory sacroiliac joints are the hallmarks of AS. These are the junction, where spine and the pelvis meet. Inflammation of this place is often associated with lower back pain, which may progressively radiate towards hips, shoulders, sacroiliac, pelvis and ribs.

Chest

Inflammation of AS, spreading up from the spine can affect other parts of the body as well, like chest. Since the thoracic ribs are attached with the spinal bones; inflammation in the spine can pressurize these joints to be stiff and tight, thus, making it difficult for expansion, while breathing.

Eyes

The expanding inflammation can pass on to reach the eyes, causing iris and uveitis. These terms describe the eye inflammation, leading to discomfort, when untreated. A person with chronic AS, may thus suffer with eye inflammation that may become bloody red or the person will be able to see dark spots.

In many cases, they may have visual difficulty, which may progress rapidly to cause permanent blindness.

Currently, there are no cure through conventional route for AS, as a matter of fact, inflammatory disorder like AS needs variable treatment approach for being cured. In this regard, stem cells and their therapeutic application are found to be very relevant. Stem cells are body’s own master cells with the ability to differentiate in any desired cell types; upon forcing through particular pathway. These stem cells can thus be isolated from body’s own potent sources, like adipose tissue and bone marrow, to be injected back at the site of injury; in order to allow regeneration of lost bone cells, reduction in the inflammation and regulation of immunity to secrete different growth factors, for functional restoration.

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Dementia Myths that should not be believed!

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Imagine anyone in your family or you yourself has been recently diagnosed with dementia; and are still struggling to know more about the disease etiology! You may as well be shocked and confused, as to how to proceed with the right diagnosis or can it really be cured or maybe you are planning about certain adaptations that everyone in your family needs to do!

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As a matter of fact, many questions might be swirling in your head, with very few apparent answers; and, in the middle of all this, one thing you are very scared of is the wrong information that is quite commonly going around, concerning dementia. Fortunately, we are here to help you sort, all your confusion and to give you a brief idea about the facts; further to which, we urge you not to believe on those myths that have been conveyed to you.

Myth 1 # Dementia is just an old age syndrome

Many of us are having a general impression that dementia is just an old age syndrome; however, studies have indicated that dementia is a milder form of neurodegenerative disorder and is not just limited to the older population. Statistics tells us that out of more than 10 million of urban population that is being battling with the diseases, like Alzheimer and/or dementia; almost up to 7% are younger generation in their mid-30’s and 40’s, suffering with the early onset dementia.

Myth 2 # It is just another form of forgetfulness

If you are ignoring your early dementia, as just another form of forgetfulness, then you are sadly mistaken. Scientists, on the contrary have described the disease as a group of symptoms, which may severely hamper cognitive, memory, thinking and social abilities of a person.

Myth 2 # It is just another form of forgetfulness

If you are ignoring your early dementia, as just another form of forgetfulness, then you are sadly mistaken. Scientists, on the contrary have described the disease as a group of symptoms, which may severely hamper cognitive, memory, thinking and social abilities of a person.

Myth 4 # If you have no family history for Alzheimer, you are not at a risk

It is usually being believed that people without any genetic predisposition are not at a risk of being affected with dementia. However, it is not true; in the sense, there are lot of environmental triggers, like chronic fatigue, stress, vitamin deficiency, air and noise pollution, etc. that have been identified recently.

Myth 5 # Once you are diagnosed with Dementia; there is no cure!

You might have been consulted through your practitioner that nothing can be done, once you are diagnosed with dementia. However, this can be considered as partially true, because conventional medicines cannot cure the issue or reverse the damage for that matter; but with technical advancements it is possible to reverse the neuronal damage associated with the condition, through administration of autologous stem cells.

Various clinical studies in this regard, have been published in the international journals; suggesting a combination of exercises, mental stimulation programmers, nutrition and stem cells therapy, to bring in the possible regenerative effect.

Myth 6 # Dementia is a normal part of ageing

Most people are forced to believe that the dementia is a normal part of ageing; and is quite obvious, if you are passed through a certain age. However, they should understand that dementia is never to be considered as normal ageing, as it is associated with lot of severe indications, Alzheimer’s disorders, Parkinson’s disease, stroke, vitamin deficiency, etc. Thus, you should not expect your cognitive functions to go down suddenly without a solid reason; and hence need an immediate medical attention.

His Highness the Amir was given a warm welcome to India, alongwith the Deputy Amir and Crown Prince Sheikh Nawaf Al-Ahmad Al-Jaber Al-Sabah.

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Sheikh Sabah IV Ahmad Al-Jaber Al-Sabah GCB (Hon) (Arabic: الشيخ صباح الأحمد الجابر الصباح born 16 June 1929) is the 15th Ruler and 5th Emir of Kuwait and the Commander of the Military of Kuwait. He was sworn in on 29 January 2006 after confirmation by the National Assembly of Kuwait. He had previously been Foreign Minister for 40 years, from 1963 to 2003, being the longest-serving foreign minister in the world. During his tenure as a Foreign Minister, Sabah restored Kuwaiti international relations after the Gulf War. He played an important role in restoring the country after the Iraqi Invasion.

His Highness Sheikh Sabah IV Ahmad Al-Jaber Al-Sabah has always been a pillar of strength and has shown time and again his ability as an able ruler in both fields of Kuwait’s Foreign and Domestic Affairs.

The Amir of Kuwait has played an important role in founding the Common Ministerial Council for the G.C.C and the European Union, which aims to consolidate and maximize economic ties between the participating countries.

His Highness Sheikh Sabah IV Ahmad Al-Jaber Al-Sabah political outlook has always been centered towards helping Arab counties and fostering a bond amongst each other and also playing a mediatory role in times of conflicts amongst Arab Nations. His Highness is playing a crucial role in mediating resumption of diplomatic and commercial ties between Qatar and several of its Arab neighbors. 

Can the problem of Nerve Damage Be Fixed!

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Different people have different kinds of experience with nerve pain. For instance, some may feel a stabbing pain, suddenly may be in the middle of the deep sleep or some may notice a kind of a tingling, burning sensation, on the go! Although, uncontrolled nerve pain can at times be unbearable, with the current available conventional treatment regimen, it can only be managed but not cured.

Some experts believe that pain can be referred to be as an indication or a warning, sent through a damaged nerve. For example, if your hand gets too close to a burner or a burning candle; you involuntarily tend to retaliate, as your nerve sends pain signals to the brain. As a matter of the fact, due to nerve damage, the signals that are being initiated towards the brain, are often identified to be the false signals; initiated without any diseased condition, pain or an injury.

Although, the good news is that nervous breakdown is a slow and gradual process; indicating a possibility to treat the issue, before it gets worsen. It is advisable thus, to consult experts, if any of the following symptoms are noted.

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Numbness, tingling and/or burning sensation

Sudden notification of numbness, tingling sensation radiating from hands or feet towards the upper portion of your body; is a primary indication of sensory nerve compression. Although, the experience can be quite temporary, repeated triggers should never be ignored.

Difficulty in moving some of the body parts

Through damaged motor nerves, it is quite possible to be affected with severely chronic weakness or even paralysis in the later stage. Thus, if you notice that you are facing difficulty in moving one or more parts of your body, it indicates an urgent need of medical attention.

Pain running down just one leg

A burning sensation with continuous sharp pain; starting in the lower back of your body and radiating towards the back of your one leg could indicate the presence of sciatica. Chronic issue of compressed and/or worn out spinal disc may damage sciatic nerve.

Clumsier attitude than usual

If you are noticing that you are suddenly tripping or falling than usual; then is the sign of damage to your sensory nerves; which can cause lack of coordination, concentration and tendency of frequent falls, in the later stage. If not taken proper medical precautions, you may face a problem of neurodegenerative diseases, such as Parkinson’s disease, Alzheimer Disease, etc.

A sudden, intense pain in the neck

Occipital neuralgia, a condition that usually may result due to pinched nerve in your neck region. You tend to get intense headache just like that of electric shocks. A nerve block is being prescribed in order to temporarily block a troublesome nerve from transmitting signals.

As a matter of fact, conventional medication cannot offer permanent cure to the problem, however, with the help of alternative medicine like stem cells therapy; it is possible to regenerate damaged nerve and restore its function back to a certain extent, if administered within early time frame.

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Chronic Back Pain- Do you really need to worry?

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Pain can be severely uncomfortable experience for many of us; for that matter, even minor pain, which generally fades away very quickly like stubbed toe or a paper cut can be disturbing, forget about the chronic pain that needs to be delved every day for the entire life!

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Thus, chronic back pain due to the diagnosis including arthritis, spinal cord injury and recurring migraines may have severely negative impact on a person’s day to day life, when not treated for a longer period of time. In many of the cases, people who are struggling with chronic back pain are noted to be irritated, short tempered and impatient, either due to anti-inflammatory steroidal drugs that have been offered to them as a mainstream treatment or due to some valid reasons. Moreover, constantly tingling pain has as well statistically detected to raise the focus threshold; thus, hampering person’s ability towards appropriate basic functioning and/or workarounds to even relatively ordinary issues. Their situation can be comparable with traffic jam; many of us are mildly annoyed with the problem but somehow manage to cope up with it, as our daily routine.

Hence, after a while a pain in back can suck your energy level and sap your motivation to work. It may as well hamper your social relationship, due to stress, lack of stamina and depression. Thus, eventually many people with depressed set of minds have been found to be associated with other issues, like lack of interpersonal interactions, lack of concentration, seeking isolation and aloofness with a strong desire to simplify many issues of life.

Some of the recent clinical investigations have related pain with chemistry of cells in neurons; thus, disconnecting their strong networking capacity. It has been evident that cellular damage in the brain stem and spinal cord region is more intense, due to chronic back pain, limiting their ability and affecting functional attributes of other vital organs.

Since, untreated pain can induce other complications related to the down regulation of central nervous system, it would be wise to take immediate medical support. Contrary to conventional treatment options, which rely mainly on anti-inflammatory medications and pain management; a multidisciplinary approach of stem cells has been studied to be more effective in offering more accurate solution. Stem cells are body’s mother cells, which have been tracked, since couple of decades for their productivity and potential to differentiate into multiple tissue specific cells that are in demand.

Hence, interdisciplinary approach of stem cells, which are to be isolated from body’s own sources like adipose tissue and/or bone marrow, processed in the laboratory for further enrichment and to be infused back through central nervous system have been noted to be the most significant way to reduce complications associated with chronic back pain and other survival consequences. Additionally, various management therapies can be offered, which may include exercise, physical therapy, a balanced diet, and a calm mental state.

Although, effectiveness of the treatment is more dependent upon the source of pain, physical and mental fitness and ability of the service provider; however, a current scenario suggests an acceptance towards stem cells therapy as a possible cure for chronic back pain.

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