Through a combinational approach of using the cutting edge stem cell technologies coupled with computational biology, a team of scientists in the University of Oxford has developed a unique way out to figure out the perfect treatment approach for managing Parkinson’s disease. The results that have been obtained through the promising study have been published in a renowned journal of molecular genetics; and are confirming the regenerative potential of stem cells isolated from autologous body sources, such as fat, bone marrow, skin, etc into dopamine-producing brain cells. Whereas, computational biology helped researchers to study the intrinsic pattern of genetic as well as cellular behavior, while stem cells were infused at the targeted side.
This breakthrough pointed out the restriction of embryonic stem cells and a need for the potential sources of stem cells, offering an unlimited supply of tissue-specific cells. In this regard, the team as well put their efforts in identifying the better source and number of stem cells, which can be molded perfectly to become cells of desirable origin.
Stem cells are the youngest original cells of the body, with the ability to differentiate into cells of any tissues, if guided through proper signaling process and directed at the site of injury. The technology has provided methods to isolate these cells outside the body, without disturbing their originality, enrich them in a controlled atmosphere to increase their number and re-introduce them back; where they are required the most.
Unlike their embryonic counterparts, these stem cells are ethically exempted and since they are isolated from autologous tissue sources; they pose a minimum threat to the body. Moreover, their presence has been noted all over the body, may it be bone marrow or fat and hence isolating them in a good number, has never been challenging.In this regard, in case of degenerative issues, such as Parkinson’s disease, wherein the dopamine-producing neurons are being damaged, resulting into tremors and lack of muscular strength; stem cells have been proven as the ‘wonder drugs’ to repair internal damage and regenerate lost cells.
Apparently, with the help of a conventional medicinal approach, a disastrous medical condition, such as Parkinson’s disease was being treated with the administration of anti-inflammatory steroidal drugs or surgery without any effective outcome. For the most advanced cases, although organ replacement was supposed to be the ultimate choice; but getting a matched organ has always been a difficulty. However, stem cells can be the most essential substitutes for an entire organ, assisting in longevity by altering intrinsic mechanisms and targeting directly only the cause of concerns; i.e. regeneration of dopamine-producing brain cells in case of Parkinson’s disease.
Although, it would be a valid acknowledgment that this innovative approach is still being highly criticized; it should be noted as the specialized treatment, which is widely assessed for its safety as well as feasibility, for the betterment of mankind. Thus, irrespective of its little motivation to make stem cells therapy routinely accessible, people should consider it as the current best available medical miracle with the capacity to alter highly incurable degenerative conditions, such as Parkinson’s disease.