Almost a couple of years ago, I was under a situation, wherein I could barely walk. I had lost my self-confidence, since my hands were extremely shaky. Slowly and progressively, I felt as if I am losing control over my life; I had actually forgotten to smile. I had given up hope, after being diagnosed with Parkinson’s disease.
A former marathon runner, Rogen Nelson, had been totally destroyed with his own nervous system; up to the extent that, he was not being able to deal with a simple act of playing his favorite game, on his own. However, thanks to the pioneering stem cells treatment, which has given hopes to millions of sufferers, like me!
It has been very apparent that you may react differently, once you come to known that you have been suffering with Parkinson’s disease. A news may either force you to feel left alone, or you may be relaxed, because after years of bouncing from one doctor to another, finally your problem has been defined. Since you might be disappointed with the news of being diagnosed with PD; it hardly matters, at what age the disease has taken control over you. For the next several months, the ultimate goal of you and your family member would be to keep you stay mentally and physically healthy and fit.
Parkinson’s disease is a typical form of progressive neurodegenerative disorders, affecting millions of people worldwide, irrespective of their gender difference, professional levels and social positions. The disease is characterized with malfunctioning of nerve cells in the brain. Generally, these nerve cells are the network of cells, responsible for passing on vital information generated in the brain, towards different functional organs of the body. This way, these cells synthesize an important chemical messenger dopamine, that is responsible for transmission of signal for controlling movement and locomotion. However, Parkinson’s brain is devoid of dopamine, due to which there is halted information for locomotion and smoother functioning of muscles. Studies have evidently suggested three different stages of the disease, which have been specified herewith.
Stage 1: This can be categorized as the initial phase, wherein a person will exhibit mild symptoms, like shaky hands, tremors, etc. Some of the very common observations, during this phase may be poor posture, loss of balance and/or abnormal facial expression.
Stage 2: Being progressive disease, second phase can be more severe in case of symptomatic observation, it may affect both the limbs, bilaterally. A problem associated with walking and balance can be more severe. Moreover, the inability to perform normal daily routines can be more obvious.
Stage 3: It is considered to be the final and the most severe stage of the disease, accompanied by severe rigidity, loss of movement, and/or muscle stiffness. A person at this stage requires constant nursing care and dependence to perform his daily routine.
Although, conventional medicine can only offer some support system and delay in disease progression, through physiotherapy and other rehabilitative approach; the advances in regenerative medicine seems to have possible therapeutic solution for PD.
The differentiation potential of stem cells can be utilized to regenerate lost dopaminergic neurons in the body, to offer some sort of functional restoration. These stem cells can be very well isolated from some of the potent autologous sources of patient’s own body, like adipose tissue and bone marrow.
Although, continuous research is still advancing, to produce more robust cells and to explore various potent routes of delivery of enriched stem cells, back into the body; the current development of stem cell models for PD have definitely shown very promising results.